Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Click arrow to playDownload TWiV 626 (98 MB .mp3, 163 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19. Click arrow to playDownload TWiV 624 (74 MB .mp3, 123 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
by Gertrud U. Rey Does a first infection with SARS-CoV-2 make a person immune to a second infection? This question is one of the prevailing issues in the current pandemic. The relevant immune response is adaptive immunity, which initiates during a first exposure to a pathogen and protects from re-infection and disease upon a second …
Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Click arrow to playDownload TWiV 621 (91 MB .mp3, 152 min)Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Show notes …
Small animal models (mice, ferrets, hamsters) are essential for understanding how SARS-CoV-2 causes disease and for pre-clinical evaluation of vaccines and antiviral therapeutics. One promising model has been developed by modifying SARS-CoV-2 so that it binds to murine ACE2. Laboratory mice cannot be infected with SARS-CoV-2 because the viral spike glycoprotein (illustrated) does not bind …
Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Click arrow to play Download TWiV 614 (100 MB .mp3, 167 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! …
