Virology Live 2021

I’m trying an experiment in teaching – I’m going to teach my introductory virology course as a livestream on YouTube. Sessions will be every Monday and Wednesday, 11 AM eastern Time. Subscribe to my YouTube channel to attend class.

Course resources

  1. You don’t need a textbook to do well in this course, but if you would like to dive into the details, I recommend Principles of Virology. Vol I: Molecular Biology, Vol. II: Pathogenesis and Control (S.J. Flint et al., Fifth Edition, ASM Press 2020). I’m one of the co-authors and Virology Live is based on this textbook.
  2. You should read virology blog for information relevant to the course.
  3. You should listen to the weekly podcast “This Week in Virology”, for lively discussions about virology with multiple hosts.
  4. Slides (pdf) will be posted at this website before each class.
  5. If you missed the livestream, the video will always be available on YouTube.

Session Schedule, 2021

DateTopicReadingSlidesStudy QuestionsVideo
9/29What is a virus?Flint Vol I Chp 1
€¢The evolving concept of virus
€¢Cell size and scale
10/4The infectious cycleFlint Vol I Chp 2
€¢Counting Viruses
€¢Viral RNA is not infectious virus
€¢I tested positive
€¢My antibody result
10/6Genomes and geneticsFlint Vol I Chp 3
€¢The Baltimore scheme
Finding the next pandemic virus
10/11StructureFlint Vol I Chp 4
€¢Buckyball Viruses (YouTube)
€¢Virus images at ViperDB
Triangulation number (pdf)
10/13Attachment and entryFlint Vol I Chp 5
€¢A portal for RNA exit
€¢A human rhinovirus in chimpanzees
10/18Synthesis of RNA from RNAFlint Vol I Chp 6
€¢Influenza viral RNA synthesis
10/20Transcription and RNA processingFlint Vol I Chp 8 through p277 Chp 10 through p364pdfpdfYouTube
10/25Viral DNA replicationFlint Vol I Chp 9
€¢No primer needed
10/27Reverse transcription and integrationFlint Vol I Chp 7
€¢Museum pelts help date the Koala retrovirus
€¢Aretrovirus makes chicken eggshells blue
€¢Reverse transcription animation
€¢Retroviral influence on human embryonic development
11/1AssemblyFlint Vol I Chapters 12 and 13
€¢Packaging of the segmented influenza virus genome
€¢What if influenza virus did not reassort?
11/3The infected cellFlint Vol I Chp 14
€¢Metabolic manipulations in virus-infected cells
€¢Rhinoviruses have a sweet tooth
11/8No class
11/10Infection basicsFlint Vol II Chapters 1 and 2
€¢Transmission of influenza
€¢Slow motion sneezing
Chikungunya an exotic virus on the move
€¢How mosquitoes spread viruses
11/15Intrinsic and innate defensesFlint Vol II Chapter 3
€¢The inflammatory response
€¢Natural antibody protects against viral infection
11/17Adaptive immunityFlint Vol II Chapter 4
My at-home SARS-CoV-2 antibody test result
11/22Mechanisms of pathogenesisFlint Vol II Chapter 5pdfpdfYouTube
11/24Acute InfectionsFlint Vol II Chapter 5
€¢Acute viral infections
€¢Chronology of an acute infection
11/29Persistent infectionsFlint Vol II Chapter 5pdfpdfYouTube
12/1Transformation and oncogenesisFlint Vol II Chapter 6pdfpdfYouTube
12/6VaccinesFlint Vol II Chapter 8
€¢Influenza virus-like particle vaccine
€¢Poliovirus vaccine safety
12/8No class
12/13AntiviralsFlint Vol II Chapter 9
€¢A new drug for influenza
12/15EvolutionFlint Vol II Chapter 10
€¢Virulence €“ a positive or negative trait for evolution?
€¢Increased fidelity reduces viral fitness
€¢Why do viruses cause disease?
12/20Emerging virusesFlint Vol II Chapter 11
€¢MERS-coronavirus in camels
€¢Nipah virus at 20
SARS-CoV-2 pandemic could have been prevented
12/22HIV and AIDSFlint Vol II Chapter 6
€¢The London Patient
€¢Interview with Beatrice Hahn
12/27Unusual infectious agentsFlint Vol II Chapter 12
€¢Is chronic wasting disease a threat to humans?
€¢Prion contamination in the emergency room
12/29Therapeutic virusesFlint Vol I Chapter 3
€¢Infectious poliovirus DNA (pdf)
TWiV 350: Viral gene therapy with Katherine High
€¢Virus Watch: Cancer killing viruses
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