COVID-19

TWiV 623: Bats and coronaviruses with Peter Daszak

1 Comment / This Week in Virology / By

Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Click arrow to playDownload TWiV 623 (41 MB .mp3, 68 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes …

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A mouse model for COVID-19

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Small animal models (mice, ferrets, hamsters) are essential for understanding how SARS-CoV-2 causes disease and for pre-clinical evaluation of vaccines and antiviral therapeutics. One promising model has been developed by modifying SARS-CoV-2 so that it binds to murine ACE2. Laboratory mice cannot be infected with SARS-CoV-2 because the viral spike glycoprotein (illustrated) does not bind …

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TWiV 617: Coronavirus Times

2 Comments / This Week in Virology / By

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Click arrow to play Download TWiV 617 (91 MB .mp3, 152 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show …

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Cigarette smoke and COVID-19

2 Comments / Basic virology, Information / By

Some evidence suggests that cigarette smokers are more likely to develop severe COVID-19 disease than non-smokers. Chronic smoke exposure appears to trigger the expansion of cell types in the respiratory tract that produce ACE2, the receptor for SARS-CoV-2. This observation provides a plausible hypothesis to explain why cigarette smokers might experience more severe COVID-19. A …

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