…over the PACE trial, the document notes more than once that the investigators themselves have responded to criticisms, citing the FAQ on the trial website and other publications. The surveillance…
…trial of treatments for chronic fatigue syndrome, published recently in The Lancet. That is not the case. The patients in this trial had a disabling chronic illness in which fatigue…
…the first place. (In contrast, it is possible to obtain viable data from open-label trials that include objective outcomes, and from blinded trials with subjective outcomes.) ***** Despite these flaws,…
…Cochrane’s Common Mental Disorders group. Last month, The Times and The BMJ covered the growing international concerns about the PACE trial. Both publications ran articles about Virology Blog’s most recent…
…Times and The BMJ covered the growing international concerns about the PACE trial. Both publications ran articles about Virology Blog’s most recent open letter to The Lancet, which cited PACE’s…
…grasp that unblinded trials relying on self-reported outcomes, like PACE, are so fraught with bias as to be uninterpretable. That’s why clinical trials with this design are never used as…
