Virology

Viral glycoproteins are not always randomly distributed

The membranes of enveloped viruses contain embedded proteins that are essential for attaching to cell receptors and fusing with cell membranes. We generally view these glycoproteins as evenly distributed over the surface of the virus particle, as illustrated for influenza virus. But many more envelope glycoproteins are involved in attachment ...

TWiV 506: A Cafeteria full of jelly rolls

The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: ...

A lytic bacterium that behaves like a virus

Proposed C. destructans life cycle. Host mitchondria is brown. Image credit. What do you call a small bacterium that acts like a virus, infecting and lysing eukaryotic cells? Chromulinavvorax destructans, of course! As part of a study to identify pathogens that infect protist zooplankton, particles smaller than 0.8 microns were ...

TWiV 505: Rosebola

The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"&gt;&lt;/span&gt;&amp;lt;span data-mce-type="bookmark" ...

Herpesviruses and Alzheimer’s Disease

Roseola. Image credit. Risk factors for the chronic neurodegenerative condition known as Alzheimer's disease (AD) include many cellular genes and pathogenic microbes. Nucleic acids of two ubiquitous human herpesviruses, HHV-6A and HHV-7, have been found at higher levels in AD brains compared with healthy controls, and appear to regulate genes ...
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