Virology

A Mouse Model System for Zika Virus Infection

Type I IFN receptor binding and signal transduction. By Gertrud U. Rey Zika virus (ZIKV) infection causes microcephaly in newborns and is causally associated with Guillian-Barré syndrome in adults. To date, there are no drugs available to prevent or treat ZIKV infection. ZIKV vaccine research is challenging because adult immunocompetent ...

TWiV 497: Europic 2018

At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"&gt;&lt;/span&gt;&amp;lt;span ...

Blocking rhinovirus infection by inhibiting a cell enzyme

N-terminal myristoylation. An amide bond links myristate to an N-terminal glycine in the myristoylation site consensus sequence. The common cold is an infection of the upper respiratory tract that may be caused by many different viruses, but most frequently by rhinoviruses. A compound that inhibits a cell enzyme and blocks ...

TWiV 496: Vaccines work, whether or not you believe in them

https://youtu.be/C0p6mlqCfVA Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" ...

Living on the edge of parasite inevitability

All life forms on Earth harbor an array of genetic parasites, including viruses, plasmids, and transposons. Unfortunately, if cells could reduce their uptake of these elements, they would suffer as the entry of beneficial genes would be impaired (link to paper). In other words, genetic parasites are unavoidable. A genetic ...
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