Some antiviral drugs, like acyclovir for treatment of herpes simplex virus infections, are chain terminators that block RNA or DNA synthesis. They are modified nucleotides that can be incorporated into a growing RNA strand, but no additional nucleotides can be added. Amazingly, a cell protein has been found that can ...

Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: ...

By Gertrud U. Rey Although antiretroviral therapy (ART) has been highly effective at controlling HIV-1 viral loads in the bloodstream of infected individuals, the virus remains latent in infected cells and starts replicating within a couple of weeks upon termination of therapy. The discovery of CRISPR/Cas9 gene editing technology has ...

The Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mt. Sinai recently conducted the first PhD Lab Coat Ceremony in New York City. I was honored to be the Keynote Speaker at this event. My address follows. Forty-three years ago this month I was in your ...

Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"&gt;&lt;/span&gt;&lt;span data-mce-type="bookmark" ...