The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Click arrow to play Download TWiV 535 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Virus particles are metastable: they must be highly stable, to protect the nucleic acid while traveling from host to host or cell to cell, and then come apart to liberate the genome into the cell. New insight into this uncoating process comes from beautiful images of feline calicivirus showing formation of a portal on the …
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Click arrow to play Download TWiV 534 (57 MB .mp3, 95 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
The gut tracts of many animals are inhabited by a microbial community composed of bacteria, archaea, fungi, and viruses. The interplay among these inhabitants can have an impact on health and disease. Mosquitoes are no exception – replication of dengue virus in the gut tract is modulated by a fungus and a bacterium.
The family of viruses known as the Filoviridae (filo, from the Latin for thread) is well known for the ebolaviruses, which cause the hemorrhagic disease that regularly erupts in Africa. As Earth€™s virome is slowly revealed, other filoviruses are discovered.
Measles virus does not just cause a rash – it can kill, up to 100,000 people each year. And there are many related viruses circulating in other animals that are not far from being able to infect human cells.
