virology

Universal influenza vaccines

The need to re-formulate the influenza virus vaccine in response to viral antigenic drift and shift makes for complex logistics of vaccine production and administration. Surveillance programs must be conducted each year to identify strains that are likely to predominate and cause disease. Wouldn€™t it be simpler if a single vaccine could be developed that …

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TWiV 102: Catch me if you can in Munich

Hosts: Vincent Racaniello, Andrew Baker, Karl-Klaus Conzelmann, Peter Palese, and Katharina Eisenächer Episode #102 of the podcast This Week in Virology is a conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense€™. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV102.mp3″] Click the arrow above to …

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TWiV #101: Sizing up adenovirus

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Hamish Young On episode #101 of the podcast This Week in Virology, Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV101.mp3″] Click the arrow above to play, or right-click to download …

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Why John Coffin doesn’t sleep well

John Coffin, Professor of Genetics and Molecular Microbiology at Tufts University, studies the molecular biology and evolution of retroviruses. He wrote a commentary (A new virus for old diseases?) that accompanied the publication by Lombardi and colleagues of the finding of the new retrovirus XMRV in patients with chronic fatigue syndrome, and has spoken widely …

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Detecting viral proteins in infected cells or tissues by immunostaining

Many virological techniques are based on the specificity of the antibody-antigen reaction. Examples in our virology toolbox include western blot analysis and ELISA. While very useful, these methods cannot be used to visualize viral proteins in infected cells or tissues. To do that we must turn to immunostaining. In direct immunostaining (illustrated), an antibody that …

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