Innately Immune
New data suggest that children are less susceptible to severe COVID-19 because they have a stronger innate immune response than adults.
RIG-I
TWiV 633: Singapore viral
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Click arrow to playDownload TWiV 633 (56 MB .mp3, 93 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
A cell RNA that regulates innate immunity
All immune responses, from intrinsic to adaptive, need to be regulated – if left on indefinitely they will damage the host. The innate immune response is no exception, and a cellular RNA has been identified that binds to a sensor of viral RNA and regulates the production of interferon (IFN).
TWiV 102: Catch me if you can in Munich
Hosts: Vincent Racaniello, Andrew Baker, Karl-Klaus Conzelmann, Peter Palese, and Katharina Eisenächer Episode #102 of the podcast This Week in Virology is a conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense€™. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV102.mp3″] Click the arrow above to …
Interfering with interferon
During a discussion about blogging on the Coast to Coast Bio Podcast, it was suggested that science professors should spend more time writing about their research – by explaining what problems they are trying to solve, how they approach them, and why they are interesting. My goal here at virology blog is mainly to teach …
How influenza virus inhibits early antiviral responses
The fact that viruses routinely and frequently cause disease shows that our defense mechanisms are imperfect. This occurs in large part because nearly every viral genome encodes one or more countermeasures to modulate host defenses. Influenza virus is no exception. One of the viral proteins, called NS1, is particularly adept at impairing the synthesis of …
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