interferon

TWiV 484: Float like a mimivirus STING like a bat

2 Comments / This Week in Virology / By

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt; Click arrow to play Download TWiV 484 (53 MB .mp3, 87 min) Subscribe (free): iTunes, RSS, email …

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Defective viral genomes and severe influenza

3 Comments / Basic virology, Information / By

The virulence of a virus – its capacity to cause disease – is determined by both viral and host factors. Even among healthy individuals, infection with a particular virus may have different outcomes ranging from benign to lethal. The study of influenza viruses that cause mild or fatal outcomes reveals that defective viral genomes play …

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TWiV 450: Ben tenOever and RNA out

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Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab’s finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life.   Click arrow to play Download TWiV 450 (58 MB .mp3, 96 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show …

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TWiV 428: Lyse globally, protect locally

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The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection. You can find TWiV #428 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV428.mp3″] Click arrow to play Download TWiV 428 (65 MB .mp3, 108 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!

TWiV 426: I’m Axl, and I’ll be your cervid today

1 Comment / This Week in Virology / By

The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells. You can find TWiV #426 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV426.mp3″] Click arrow to play Download TWiV 426 (66 MB .mp3, 110 min) Subscribe …

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