TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19.
Cigarette smoking appears to be associated with more severe COVID-19, but the underlying mechanisms have not been deciphered. The results of infection of airway cells in culture with SARS-CoV-2 provide some insight. Smoking is the most important cause of chronic lung disease, which in turn is a risk factor for severe COVID-19. Some studies have …
Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions. Click arrow to playDownload TWiV 671 (102 MB .mp3, 170 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become …
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Click arrow to playDownload TWiV 633 (56 MB .mp3, 93 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2. Click arrow to play Download TWiV 597 (69 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
All immune responses, from intrinsic to adaptive, need to be regulated – if left on indefinitely they will damage the host. The innate immune response is no exception, and a cellular RNA has been identified that binds to a sensor of viral RNA and regulates the production of interferon (IFN).