Innately Immune
New data suggest that children are less susceptible to severe COVID-19 because they have a stronger innate immune response than adults.
ACE2
Dynamics of SARS-CoV-2 Vaccine-Induced Antibody Immunity
It is slowly becoming clear that the immunity induced by SARS-CoV-2 vaccination is of overall better quality than that induced by COVID-19.
TWiV 690: This is your brain on SARS-CoV-2
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients. Click arrow to playDownload TWiV 690 (71 MB .mp3, 120 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
TWiV 675: Forget what you’ve herd about immunity
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Click arrow to playDownload TWiV 675 (105 MB .mp3, 174 min)Subscribe (free): iTunes, Google …
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TWiV 626: Ralph Baric and fancy ferrets
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Click arrow to playDownload TWiV 626 (98 MB .mp3, 163 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
A mouse model for COVID-19
Small animal models (mice, ferrets, hamsters) are essential for understanding how SARS-CoV-2 causes disease and for pre-clinical evaluation of vaccines and antiviral therapeutics. One promising model has been developed by modifying SARS-CoV-2 so that it binds to murine ACE2. Laboratory mice cannot be infected with SARS-CoV-2 because the viral spike glycoprotein (illustrated) does not bind …