by Gertrud U. Rey Remember the series of flashbacks in the ending of the movie “Contagion,” which reveal where the virus originated and how the pandemic started? As a tree is cut down, a colony of bats flies out of the tree to seek new shelter. While in flight over a nearby farm, one of …
Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.
TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection.
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait.
Rhesus macaques that are vaccinated against SARS-CoV-2 are protected from severe disease and probably transmit very little virus when infected with SARS-CoV-2 one year later.
Various SARS-CoV-2 like viruses have been isolated from bats in China, Thailand, and Japan, but none have a spike protein that can bind ACE2 and allow entry into human cells. Sampling of bats in Laos has now revealed the presence of such viruses. The genome of a virus called RaTG13, from Rhinolophus affinis bats in …