A request for data from the PACE trial
…in requesting the trial data.) These flaws include, but are not limited to: major mid-trial changes in the primary outcomes that were not accompanied by the necessary sensitivity analyses; thresholds…
Search Results for: Trial by Error
An open letter to The Lancet, again
On November 13th, five colleagues and I released an open letter to The Lancet and editor Richard Horton about the PACE trial, which the journal published in 2011. The study’s…
An open letter to Dr. Richard Horton and The Lancet
…links in The Lancet but did not inform trial participants, contrary to their protocol commitment. This serious ethical breach raises concerns about whether the consent obtained from the 641 trial…
Why don’t DNA based organisms discard error repair?
…reproduction are evolutionarily sustainable: shorter RNAs with lots of errors; longer DNAs with fewer errors. The reader who posed the original question then came back with this retort: If reduced…
Trial by Error, Continued: University of Bristol Responds, Sort Of
…prolonged silence from Professor Crawley indicated to any reasonable observer that she could not defend her allegation, and that I took this as her tacit acknowledgment of error. I also…
Trial By Error: Yet Another Go-Round with BMJ Open
…acknowledge its error in publishing a research paper without ethical review, and then take the necessary steps to resolve the problem. Vincent R. Racaniello, PhD Professor of Microbiology and Immunology…