…COVID: a meta-analysis of randomized controlled trials,” from Tan et al, reported “high-certainty evidence” in favor of exercise interventions, and suggested they “should be prioritized.” My letter challenged that perspective….
…error threshold – a situation called error catastrophe – but there has been little experimental support for this hypothesis. An analysis of poliovirus RNA synthesis suggests that this hypothesis is…
…in requesting the trial data.) These flaws include, but are not limited to: major mid-trial changes in the primary outcomes that were not accompanied by the necessary sensitivity analyses; thresholds…
On November 13th, five colleagues and I released an open letter to The Lancet and editor Richard Horton about the PACE trial, which the journal published in 2011. The study’s…
…links in The Lancet but did not inform trial participants, contrary to their protocol commitment. This serious ethical breach raises concerns about whether the consent obtained from the 641 trial…
…reproduction are evolutionarily sustainable: shorter RNAs with lots of errors; longer DNAs with fewer errors. The reader who posed the original question then came back with this retort: If reduced…
