…trial of the Lightning Process as a treatment for pediatric CFS/ME, which was conducted by investigators from the University of Bristol (UoB) and published in Archives of Disease in Childhood…
…bin. As I have pointed out repeatedly, the Bristol University investigators recruited more than half their participants before trial registration, swapped outcome measures based on the early results, and then…
…overlooks what happens in trials with unblinded interventions that rely on self-reported outcomes, like the Lightning Process and PACE trials. In these cases, investigators are likely to be aware of…
…the same as that behind the PACE trial, except in this case the psychological entity that is presumed to inhibit patients from engaging in activity is called “health anxiety” rather…
…the PACE trial. Overview The PACE trial was a randomized controlled trial of four non-pharmacological treatments for 641 patients with chronic fatigue syndrome (CFS) attending secondary care clinics in the…
…I critiqued here. That program, METRIC, is based squarely on PACE and its so-called “sister trial,” the FINE trial. (Professor Chew-Graham was a co-author of the FINE trial.) These trials, and…
