…was vexatious. In ordering the liberation of the raw, anonymized trial data, the First-Tier Tribunal also noted widespread concern in the scientific world about the PACE trial’s irregularities. In particular,…
…because the investigators sought ethical approval to extend their feasibility trial into the full trial while simultaneously swapping primary and secondary outcome measures based on those feasibility trial results. This…
By David Tuller, DrPH Last year, BMJ Open published a paper called Randomised controlled trial of online continuing education for health professionals to improve the management of chronic fatigue syndrome:…
…a prime example of MUS. The push to treat patients identified with MUS through IAPT has been under development for several years. The reported findings of the PACE trial in…
…study, which was then extended into a full trial of more than 220 participants. Yet the full trial’s primary and secondary outcomes were designated only after the feasibility study participants…
…as happened in PACE, that automatically invalidates the work as legitimate science. The PACE trial illustrates exactly how NOT to conduct a clinical trial. My Columbia colleague, biostatistician Bruce Levin,…
