Search Results for: Trial by Error

…study, which was then extended into a full trial of more than 220 participants. Yet the full trial’s primary and secondary outcomes were designated only after the feasibility study participants…

…as happened in PACE, that automatically invalidates the work as legitimate science. The PACE trial illustrates exactly how NOT to conduct a clinical trial. My Columbia colleague, biostatistician Bruce Levin,…

…called “Clinical and cost-effectiveness of the Lightning Process in addition to specialist medical care for paediatric chronic fatigue syndrome: randomised controlled trial.” Yet the Lightning Process trial and paper are…

…trial of the Lightning Process as a treatment for pediatric CFS/ME, which was conducted by investigators from the University of Bristol (UoB) and published in Archives of Disease in Childhood…

…bin. As I have pointed out repeatedly, the Bristol University investigators recruited more than half their participants before trial registration, swapped outcome measures based on the early results, and then…

…overlooks what happens in trials with unblinded interventions that rely on self-reported outcomes, like the Lightning Process and PACE trials. In these cases, investigators are likely to be aware of…