The bacteria in our intestines outnumber by tenfold the 100 trillion cells that comprise the human body. This gut microbiota has many beneficial functions, including the production of vitamins and hormones, fermentation, regulation of gut development, and shaping intestinal immune responses. They also play a role in pathological conditions such as diabetes and obesity, and …
Gut microbes influence defense against influenza Read More »
This article was written for extra credit by a student in my virology course. by Bethany DiPrete Human papillomavirus (HPV) infection is the most common sexually transmitted disease in the United States, and as of yet, there is no cure. However, there is a vaccine to prevent infection by certain strains. Recent research may encourage not …
Women AND men beware: HPV, the culprit behind more than just cervical cancers? Read More »
I just returned from a 17-day, 3,000 km road trip with my family in Europe. When I travel I’m always on the lookout for virus-related information and I found some at the Deutsches Museum in Munich, Germany. This museum showcases science and technology – it has over 100,000 objects illustrating the historical progression of areas such …
Thirty years ago this month I did an experiment that set the course of my career, and provided an important step forward for animal virology. I showed that a cloned DNA copy of the poliovirus RNA genome is infectious in mammalian cells. When I arrived as a postdoctoral fellow in the laboratory of David Baltimore …
Yesterday I terminated the last remaining mice in my small colony, including the line of poliovirus receptor transgenic mice that we established here in 1990. Remarkably, I had never written about this animal model for poliomyelitis which has played an important role in the work done in my laboratory. While I was still working on …
Analysis of poliovirus recovered from the stool of a patient with fatal poliomyelitis revealed that she had been infected with the virus 12 years earlier, probably when one of her children received the oral poliovirus vaccine. This case has the longest known incubation period for vaccine-derived poliomyelitis, and highlights our still rudimentary understanding of how …
Poliomyelitis after a twelve year incubation period Read More »
