Basic virology

Preliminary phase I/II results of ChAdOx1 SARS-CoV-2 vaccine

by Gertrud U. Rey On July 20, 2020, Oxford University’s Jenner Institute and the pharmaceutical company AstraZeneca reported preliminary results from phase I/II clinical trials assessing the safety and efficacy of a vaccine candidate against SARS-CoV-2.  The vaccine candidate, named AZD1222 (referred to in the publication as ChAdOx1 nCoV-19), consists of an adenovirus vector with an …

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No evidence for increased human transmission of SARS-CoV-2

Don’t believe the headlines that SARS-CoV-2 is becoming more transmissible! Virologists are making conclusions that are not justified by the data. SARS-CoV-2 virus isolates from many parts of the world have a single amino acid change in the spike protein, D614G. This observation in itself doesn’t mean very much. It could be that the change …

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The role of children in transmission of SARS-CoV-2

by Gertrud U. Rey It is well established that children experience less severe disease after infection with SARS-CoV-2. However, to what extent infected children contribute to transmission of the virus is less clear. This topic is of great interest as we prepare for the start of a new school year.  Are children less susceptible to infection …

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