When Viruses Collide with Parasitic Worms
Infection with some parasitic worms may lead to an impaired immune response against pathogenic infections by other parasites, bacteria, and some viruses.
Basic virology
T cells will save us from COVID-19, part two
T cells are the other arm of the adaptive immune response (in addition to B cells) that are essential for clearing virus infections. Most studies of immunity to SARS-CoV-2 infection have focused on antibodies and their ability to neutralize virus infection. The observation that variants of concern are less effectively neutralized by antibodies against ancestral …
Novel human coronaviruses from pigs and dogs
Recently isolated coronaviruses from humans in Haiti and Malaysia appear to have originated in pigs and dogs.
A genetically stable attenuated poliovirus vaccine
Eradication of poliomyelitis appears to be on track: types 2 and 3 polioviruses have been declared eradicated, and in the past 12 months there have been just 338 cases of type 1 polio in Afghanistan and Pakistan. But there have also been 491 cases of polio caused by the type 2 Sabin vaccine. The development …
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Early Immune Responses to Herpes Simplex Virus Type I Infection
Early interactions of herpes simplex virus type 1 with the immune system involve both Langerhans cells and a newly characterized dendritic cell. Understanding the dynamics of these initial interactions of the virus with cells of the immune system may result in better strategies for HSV-1/-2 vaccines.
Defective genomes modulate respiratory syncytial virus pathogenesis
During viral replication, defective genomes may arise that lack essential sequences. These so-called defective genomes cannot replicate unless they are in the same cell as a helper virus. Defective genomes play a role in modulating pathogenesis of respiratory syncytial virus in humans. Copy-back defective viral genomes (cbDVGs) of RSV arise when the viral RNA polymerase …
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