Basic virology

Influenza 101

Soon after the new influenza H1N1 strain emerged in April 2009, I began a series of blog posts on basic aspects of influenza virus replication and pathogenesis. The goal of this series is to provide information that will allow everyone to better understand the events surrounding emergence and spread of the new pandemic strain. Unfortunately …

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Pathogenesis of influenza in humans

When influenza virus is introduced into the respiratory tract, by aerosol or by contact with saliva or other respiratory secretions from an infected individual, it attaches to and replicates in epithelial cells. The virus replicates in cells of both the upper and lower respiratory tract. Viral replication combined with the immune response to infection (which …

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Enterovirus 71 Outbreak in Asia

There is an ongoing outbreak of enterovirus 71 (EV71) in a broad region of Asia, including China, Vietnam, Mongolia, Taiwan, and Singapore. There have been 3606 cases in China, including 36 deaths. Infection with EV71 is common in Asia, where it causes hand-foot-and-mouth disease in children, a febrile syndrome accompanied by flat or raised red …

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