Virology lecture #1: What is a virus?
Larger versions: .wmv (612 MB) | .mp4 (87 MB) Visit the virology W3310 home page for a complete list of course resources.
Basic virology
A new virology course at Columbia University
Tomorrow is the start of my new virology course at Columbia University. The course, Biology W3310, is aimed at advanced undergraduates and will be taught at the Morningside Campus of Columbia University. Columbia University encompasses two principal campuses: the historic, neoclassical campus in the Morningside Heights neighborhood and the modern Medical Center further uptown, in …
Bornavirus DNA in the mammalian genome
The chromosomal DNA of several mammals has been found to contain sequences related to the nucleoprotein (N) gene of bornaviruses, enveloped viruses with a negative-strand RNA genome. I am amazed by this finding. How did bornaviral DNA get in our chromosomes, and what is it doing there? A search of the human genome sequence revealed DNA …
Reinfection with 2009 influenza H1N1
In healthy individuals, the first encounter with a virus leads to a primary antibody response. When an infection occurs with the same or a similar virus, a rapid antibody response occurs that is called the secondary antibody response. Antibodies are critical for preventing many viral infections, including influenza. But reinfection may occur if we encounter the same …
Influenza neuraminidase inhibitors work
In the wake of a British Medical Journal article which concludes that Tamiflu has at best a modest effect, many readers have asked if influenza neuraminidase inhibitors function at all. If you’d like a good critique of this study, I suggest reading Paul Revere’s analysis at Effect Measure. For our part, we’ll examine some of …
Influenza virus growth in eggs
Before the development of cell culture, many viruses were propagated in embryonated chicken eggs. Today this method is most commonly used for growth of influenza virus. The excellent yield of virus from chicken eggs has led to their widespread use in research laboratories and for vaccine production. In fact the vast majority of influenza vaccines …