My Zoom Bookshelf
In this short video, I take you through some of the science books on my bookshelf, next to the desk where lately I have been spending a lot of time on Zoom. Not surprisingly, most of the books are about viruses.
TWiV 677: Does antibody really know what time it is?
Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more. Click arrow to playDownload TWiV 677 (97 MB .mp3, 162 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become …
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Antiviral antibodies in COVID-19 patients
In infectious disease world, the term €œcorrelate of protection€ refers to something that can be measured – antibodies or T cells – which indicates that a person is protected against infection or disease. The correlates of protection for SARS-CoV-2 infection of humans are not yet known – after all it is still early in this …
TWiV 676: Tragic gene flow from Neanderthals
In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.
TWiV 675: Forget what you’ve herd about immunity
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Click arrow to playDownload TWiV 675 (105 MB .mp3, 174 min)Subscribe (free): iTunes, Google …
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An explanation for the low quality antibodies produced during serious SARS-CoV-2 infection
Although we are less than a year into the SARS-CoV-2 pandemic, it appears that the antibodies induced by infection are often of poor quality, and B cell memory seems limited. An explanation for this outcome might be a consequence of the loss of germinal centers in COVID-19 patients. Examination of lymph nodes and spleen of …