Human monoclonal antibodies that block infection with SARS-CoV-2 are being used to treat COVID-19 patients, but an alternative, antibodies produced in camelids (alpacas and llamas) might have advantages. Camelid monoclonal antibodies can be more cheaply produced in mass quantities in bacteria, and protein engineering can be quickly used to produce a better therapeutic product. Human …
by Paul Bieniasz Dr. Bieniasz is Professor and Investigator of the Howard Hughes Medical Institute at Rockefeller University. As viruses go, SARS-CoV-2, is quite easy to neutralize with antibodies and, it turns out, straightforward to generate effective vaccines based on the spike protein. Perhaps, even probably, those two properties are causally related. Moreover, it appears …
A variant of SARS-CoV-2 has been spreading within England, and it has been suggested that this virus is more transmissible. In this video Vincent explains the properties of the SARS-CoV-2 UK variant and why claims that it is more transmissible are not supported by experimental data. This video was recorded on Monday, 21 December 2020. …
by Helen Stillwell The results from a phase I clinical trial to test the safety and immunogenicity of a universal flu vaccine candidate reported encouraging results €“ strong titers of broad and functional antibodies persisted for over a year in healthy adults following vaccination. Influenza viruses contain segmented RNA genomes. The viral envelope contains two types glycoproteins …
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On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Click arrow to playDownload TWiV 693 (69 MB .mp3, 115 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
COVID-19 vaccine candidates are garnering all the news these days, which is appropriate as they are our key to ending this pandemic. Earlier in this outbreak antiviral drugs received a good deal of attention, but they have proven less useful in curtailing infection. Less discussed are the many antiviral drug candidates that are in testing, …
An antiviral compound that blocks SARS-CoV-2 transmission in ferrets Read More »
