Virology
TWiV Special: David Tuller is PACEman
By Vincent Racaniello
David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span><span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: ...
TWiV 507: The fusion of form and function
By Vincent Racaniello
The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span><span data-mce-type="bookmark" style="display: inline-block; ...
Viral glycoproteins are not always randomly distributed
By Vincent Racaniello
The membranes of enveloped viruses contain embedded proteins that are essential for attaching to cell receptors and fusing with cell membranes. We generally view these glycoproteins as evenly distributed over the surface of the virus particle, as illustrated for influenza virus. But many more envelope glycoproteins are involved in attachment ...
TWiV 506: A Cafeteria full of jelly rolls
By Vincent Racaniello
The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span><span data-mce-type="bookmark" style="display: inline-block; width: ...
A lytic bacterium that behaves like a virus
By Vincent Racaniello
Proposed C. destructans life cycle. Host mitchondria is brown. Image credit. What do you call a small bacterium that acts like a virus, infecting and lysing eukaryotic cells? Chromulinavvorax destructans, of course! As part of a study to identify pathogens that infect protist zooplankton, particles smaller than 0.8 microns were ...