Virology
Enterovirus D68 and childhood paralysis
By Vincent Racaniello
The Centers for Disease Control and Prevention thinks that viruses play a role in the childhood paralysis called acute flaccid myelitis (AFM). The finding of antibodies to enterovirus D68 (EV-D68) in the cerebrospinal fluid of patients with AFM strengthens the link between infection with this virus and AFM. Acute flaccid ...
TWiV 560: CEIRS, influenza and company
By Vincent Racaniello
https://youtu.be/4O2j3n1RBiA From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations. Click arrow to play Download TWiV 560 (37 MB .mp3, 61 min) Subscribe ...
Avoiding error catastrophe with recombination
By Vincent Racaniello
RNA viruses exist close to their error threshold, the point beyond which additional mutations cause loss of infectivity. It has been suggested that RNA recombination prevents viruses from exceeding the error threshold - a situation called error catastrophe - but there has been little experimental support for this hypothesis. An ...
TWiV 559: Nectin connection what’s your infection?
By Vincent Racaniello
The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells. Click arrow to play Download TWiV 559 (65 MB .mp3, 108 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!
Viruses and autoimmunity
By Gertrud U. Rey
by Gertrud U. Rey Type 1 diabetes is an organ-specific autoimmune disease that is characterized by the loss of insulin-producing beta cells in the pancreas. The loss of these cells leads to decreased insulin production (hypoinsulinemia) and increased levels of glucose in the blood (hyperglycemia). While it is still unclear ...