Adenovirus associated virus (AAV) vectors are being increasingly used for gene therapy because they are not pathogenic in humans and persist for long periods in certain cell types. Currently 120 gene delivery clinical trials with these vectors are in progress, and two have been approved: Luxturna to treat a rare ...

From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more. Click arrow to play Download TWiV 574 (43 MB .mp3, 71 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses. Click arrow to play Download TWiV 573 (69 MB .mp3, 113 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

by Gertrud U. Rey Australian koalas are currently being invaded by koala retrovirus A (KoRV-A), a virus that causes an AIDS-like immunodeficiency and makes infected koalas more susceptible to cancers and opportunistic infections such as chlamydia. Retroviruses owe their name to their replication cycle, because their RNA genomes are reverse ...

Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Click arrow to play Download TWiV 572 (73 MB .mp3, 121 ...