Virology
New influenza antiviral drugs
By Vincent Racaniello
The success in treating AIDS with multiple combinations of three antiviral drugs is a model for the successful management of viral resistance. Can we expect that a deep arsenal of anti-influenza virus drugs will be developed? So far we have three antiviral drugs against influenza viruses. Most H3N2 strains are ...
John Updike, 1932-2009
By Vincent Racaniello
Here is my favorite poem about science. I found it stuck on the wall in my empty lab when I first came to Columbia in the fall of 1982. It is still tacked to my corkboard, yellowing and frayed. V.B. Nimble, V.B. Quick (inspired by V.B. Wigglesworth, F.R.S., Quick Professor ...
Integration of arenavirus DNA into the cell genome
By Vincent Racaniello
Is that title correct? Arenaviruses have an RNA genome which is not known to be copied into DNA at any stage of the replication cycle. How could a DNA copy of this virus be produced and be inserted into the host genome? The RNA genome of retroviruses is converted to ...
Ebola in pigs – Nipah redux?
By Vincent Racaniello
Ebola virus infection was reported in Phillipine pigs in 2008. This past week it was revealed that the virus was apparently transmitted from Phillipine pigs to a pig farmer. Why do these events bring Nipah virus to mind? The Ebola virus that was found in 4 of 6,000 pigs in ...
TWiV #17: Seminal discoveries in virology
By Vincent Racaniello
On This Week in Virology episode #17, Vincent, Dick, and guest Saul Silverstein talk about discoveries in virology that have had a major impact on the field. By seminal, we mean "strongly influencing later developments". Click the arrow above to play, or right-click to download TWiV #17