The WHO strategy to eradicate poliomyelitis depends upon immunization of every child under 5 years of age, and nationwide AFP (acute flaccid paralysis) surveillance to identify cases of poliomyelitis. A laboratory network then determines whether AFP is caused by poliovirus. Recently a new member of the picornavirus family was identified ...

The innate response to virus infection is a marvel: when confronted with an invading microbe, it responds rapidly by producing interferons and other cytokines which establish an antiviral state. Its effectiveness is underscored by the fact that every viral genome must encode countermeasures that modulate its activity. A recent paper ...

On This Week in Virology #18, Vincent, Dick, and Alan discuss adenovirus type 36 and obesity, new influenza antiviral drugs, viral hemorrhagic septicemia virus of fish, and Ebola virus in pigs and pig farmers in the Phillipines. Click the arrow above to play, or right-click to download TWiV #18

The past week brought an animated discussion triggered by an article in Obesity which reported the adipogenic effect of adenovirus type 36 infection in cultured cells. The press had a field day with headlines like 'Can a common cold virus really make you fat'?. Reactions on Twitter and blogs ranged ...

The innate immune system responds within minutes of infection to produce type I interferons and pro-inflammatory cytokines. Interferons induce the synthesis of cell proteins with antiviral activity, and also shape the adaptive immune response by priming T cells. Despite the discovery of interferons over 50 years ago, only recently have ...