Virology

Co-circulation of three human influenza A subtypes

Although the new influenza H1N1 strain has been receiving a great deal of attention, apparently last season's H1N1 and H3N2 strains continue to circulate, at least in the United States. FluView, the weekly surveillance report from the CDC, indicates that during weeks 17 and 18, seasonal influenza A (H1), A ...

TWiV 32: Influenza in silico

On episode #32 of the podcast This Week in Virology, Vincent, Alan, and Raul Rabadan converse about polio survivors in iron lungs, bocavirus, structure of mimivirus, and genome sequence analysis of influenza H1N1 viruses. [powerpress url="http://traffic.libsyn.com/twiv/TWiV032.mp3"] Click the arrow above to play, or right-click to download TWiV #32 or subscribe ...

Increased fidelity reduces viral fitness

We have spent over a week discussing the effects of polymerase error rates on viruses. RNA viruses have the highest error rates in nature, a property that is believed to benefit the viral population. For example, selective pressure from the immune system or antiviral drugs may lead to changes that ...

Pushing viruses over the error threshold

The capacity of RNA viruses to produce prodigious numbers of mutations is a powerful advantage. But remember that selection and survival must balance genetic fidelity and mutation rate. Many mutations are not compatible with viral replication. Consequently, if mutation rates are high, at some point accumulating base changes lead to ...

Influenza A/Mexico/2009 (H1N1) – Questions & Answers

Here are answers to questions sent to virology blog about the new strain of influenza H1N1 that continues to spread globally. Q: Are you aware of efforts to make the virus strain nomenclature more informative? Understanding what segments/genes are related historically and sequence wise to what is confusing  using the ...
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