Virology
Congenital Zika Syndrome
By Vincent Racaniello
Data from several clinical studies in Brazil establish a strong link between infection of pregnant women with Zika virus and a variety of birth defects collectively called congenital Zika syndrome. In the latest study conducted in Rio de Janeiro, the authors enrolled 88 pregnant women who had a rash in the previous 5 days. ...
TWiV 379: A mouse divided
By Vincent Racaniello
On episode #379 of the science show This Week in Virology, Scott Tibbetts joins the TWiVirate to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature. You can find TWiV #379 at microbe.tv/twiv, or ...
A promising Ebolavirus antiviral compound
By Vincent Racaniello
A small molecule antiviral compound has been shown to protect rhesus monkeys against lethal Ebolavirus disease, even when given up to three days after virus inoculation. The compound, called GS-5734, is a nucleoside analog. After uptake into cells, GS-5734 is converted to a nucleoside triphosphate (illustrated, bottom panel) which is incorporated by ...
TWiV 378: Herpes plays DUBstep
By Vincent Racaniello
On episode #378 of the science show This Week in Virology, Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week's news about Zika virus. You can find TWiV #378 at microbe.tv/twiv, or you may listen below. [powerpress url="http://traffic.libsyn.com/twiv/TWiV378.mp3"] ...
Person to person Zika virus transmission
By Vincent Racaniello
The title of a Eurosurveillance article, "An autochthonous case of Zika due to possible sexual transmission, Florence, Italy, 2014" was written to make the headlines. The title should be "An autochthonous case of Zika due to person to person contact, Florence, Italy, 2014." An Italian man returns from a 10 day holiday in Thailand and ...