Virology
TWiV 382: Everyone’s a little bit viral
By Vincent Racaniello
On episode #382 of the science show This Week in Virology, Nels Elde and Ed Chuong join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses. You can find TWiV #382 at ...
Top secret, viruses with RNA genomes!
By Vincent Racaniello
Today it is well known that viruses may contain DNA (poxvirus, mimivirus) or RNA (influenza virus, Zika virus), but for many years it was thought that genomes were only made of DNA. The surprise at finding only RNA in a virus is plainly evident in a 1953 letter from Harriett Ephrussi-Taylor to James D. Watson ...
TWiV 381: Add viruses and Zimmer
By Vincent Racaniello
On episode #381 of the science show This Week in Virology, Carl Zimmer joins the TWiV team to talk about his career in science writing, the real meaning of copy-paste, science publishing, the value of Twitter, preprint servers, his thoughts on science outreach, and much more. You can find TWiV #381 ...
Understanding viruses
By Vincent Racaniello
If you want to understand life on Earth, you need to know about viruses. We have reached the halfway point in my 2016 Columbia University undergraduate virology course. So far we have learned the basics of virus replication: how viruses enter cells, how the genome is reproduced, and how proteins are ...
Moving beyond metagenomics to find the next pandemic virus
By Vincent Racaniello
I was asked to write a commentary for the Proceedings of the National Academy of Sciences to accompany an article entitled SARS-like WIV1-CoV poised for human emergence. I'd like to explain why I wrote it and why I spent the last five paragraphs railing against regulating gain-of-function experiments. Towards the end of ...
