Virology

TWiV 436: Virology above Cayuga’s waters

At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals. You can find TWiV #436 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 436 (71 MB .mp3, ...

Forget the fourth domain of life

When giant viruses were discovered - with genomes much larger than any previously seen - some suggested that they had descended from a fourth domain of life (the current three are bacteria, archaea, and eukaryotes). Part of the reason for such a claim was the finding of homologs of bacterial ...

TWiV 435: Two virus particles walk into a cell

The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque. You can find TWiV #435 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 435 (73 MB .mp3, 121 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!

The purity of plaques

The plaque assay - my favorite assay in the world - is a time-honored procedure to determine the number of viruses in a sample, and to establish clonal virus stocks. The  linear relationship between the number of infectious particles and the plaque count (illustrated; image credit) shows that one infectious particle is ...

TWiV 434: Live long and pupate

The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host. You can find TWiV #434 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 434 (64 MB .mp3, 106 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
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