viral

Influenza A/Mexico/2009 (H1N1): Absence of crucial virulence marker

The second RNA segment of the influenza virus genome encodes two proteins, PB1 and PB1-F2.  The latter protein is believed to be an important determinant of virulence of influenza virus. Can we learn anything about the virulence of the new influenza virus H1N1 strains from a study of this protein? During influenza virus infection, PB1-F2 …

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Influenza virus RNA: Translation into protein

Let’s resume our discussion of the influenza virus genome. Last time we established that there are eight negative-stranded RNAs within the influenza virion, each coding for one or two proteins. Now we’ll consider how proteins are made from these RNAs. Figure 1 shows influenza RNA segment 2, which encodes two proteins: PB1 and PB1-F2. The …

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Oseltamivir resistance decreases influenza aerosol transmission

The isolates of influenza virus obtained in the current global outbreak have proven to be resistant to the adamantane antivirals, but susceptible to oseltamivir (Tamiflu) and zanamivir (Relenza). Consequently the two neuraminidase inhibitors will likely be used extensively to control the outbreak until a vaccine is available. Extended use of the antiviral drugs will undoubtedly …

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