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TWiV 348: Chicken shift

On episode #348 of the science show This Week in Virology, Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek’s disease viral vaccine that allows transmission of virulent viruses. You can find TWiV #348 at www.microbe.tv/twiv.

A WORD on the constraints of influenza virus evolution

Evolution proceeds by selection of mutants that arise by error-prone duplication of nucleic acid genomes. It is believed that mutations that are selected in a gene are dependent on those that have preceded them, an effect known as epistasis. Analysis of a sequence of changes in the influenza virus nucleoprotein provides clear evidence that stability …

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Why do viruses cause disease?

Virulence, the capacity to cause disease, varies markedly among viruses. Some viruses cause lethal disease while others do not. For example, nearly all humans infected with rabies virus develop a disease of the central nervous system which ultimately leads to death. In contrast, most humans are infected with circoviruses with no apparent consequence. Is there …

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TWiV 146: Draco’s potion

Hosts: Vincent Racaniello, Rich Condit, and Abbie Smith Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV146.mp3″] Click the arrow above to play, or right-click to download TWiV 146 (78 MB .mp3, 107 minutes). Subscribe to TWiV (free) in iTunes , at the Zune …

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