poliovirus

Whole plant cells producing viral capsid protein as a poliovirus vaccine candidate

Basic virology, Information / By

Although the use of the live, attenuated (Sabin) poliovirus vaccines has been instrumental in nearly eradicating the virus from the planet, the rare reversion to virulence of these strains has lead to the World Health Organization to recommend their replacement with inactivated poliovirus vaccine (IPV). Unfortunately IPV is also not without shortcomings, including high cost, failure …

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From trivalent to bivalent oral poliovirus vaccine

Basic virology, Information / By

For the first time since April of 1955, recipients of poliovirus vaccine will no longer receive all three serotypes. This past Sunday the World Health Organization orchestrated a synchronized switch from trivalent to bivalent oral poliovirus vaccine (OPV) in 150 countries. The reason for the switch is clear: type 2 poliovirus was declared eradicated last year, and the …

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TWiV

TWiV 374: Discordance in B

This Week in Virology / By

On episode #374 of the science show This Week in Virology, the TWiVniks consider the role of a cell enzyme that removes a protein linked to the 5′-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt’s lymphoma. You can find TWiV #374 at microbe.tv/twiv.

The switch from trivalent to bivalent oral poliovirus vaccine: Will it lead to polio?

4 Comments / Basic virology, Information / By

In four months, 155 countries will together switch from using trivalent to bivalent oral poliovirus vaccine. Will this change lead to more cases of poliomyelitis? There are three serotypes of poliovirus, each of which can cause paralytic poliomyelitis. The Sabin oral poliovirus vaccine (OPV), which has been used globally by WHO in the eradication effort, is …

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TWiV 371: Sympathy for the devil

This Week in Virology / By

On episode #371 of the science show This Week in Virology, the TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era. You can find TWiV #371 at www.microbe.tv/twiv.

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