Kymriah

TWiV 459: Polio turns over a new leaf

1 Comment / This Week in Virology / By Vincent Racaniello

The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants. Click arrow to play Download TWiV 459 (63 MB .mp3, 105 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

The $475,000 drug

3 Comments / Basic virology, Information / By Vincent Racaniello

The US Food and Drug Administration recently approved the first gene therapy, Kymriah, to treat B-cell acute lymphoblastic leukemia. It uses a lentivirus to modify the patient’s T cells to kill tumor cells. Acute lymphoblastic leukemia, or ALL, is caused by uncontrolled growth of B cells, which normally produce antibodies to fight off infections. It …

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Kymriah

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