An important question about the retrovirus XMRV, which has been implicated in prostate cancer and chronic fatigue syndrome, is where the virus replicates in humans. Such information would provide clues about how infection might be transmitted. To date the virus has been detected in malignant prostate cells and in the peripheral blood mononuclear cells and …
Hosts: Vincent Racaniello and Rich Condit On episode #81 of the podcast This Week in Virology, Vincent and Rich answer listener questions on viruses and gluten allergy, RNA silencing, influenza virus, herpes simplex virus, HIV/AIDS, chronic fatigue syndrome, manicure salons, and the koala tea of Marseilles. This episode is sponsored by Data Robotics Inc. Use …
Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution located in the eponymous town on Long Island, New York. Over 400 scientists work there on a wide range of biological problems, including cancer, neurobiology, plant genetics, and genomics. CSHL has a storied research history, having hosted nine Nobel Laureates. But it is also well …
All mammalian genomes contain genes encoding Apobec proteins. Several members of this protein family (the name stands for apolipoprotein B mRNA editing complex) are induced by interferon and are intrinsic antiretroviral proteins. Apobec proteins inhibit the replication of XMRV, a new human retrovirus associated with prostate cancer and chronic fatigue syndrome. During retroviral replication, Apobec …
Inhibition of XMRV by a weapon of mass deamination Read More »
Xenotropic murine leukemia virus related virus (XMRV) has been implicated in prostate cancer and chronic fatigue syndrome (CFS). Because XMRV is a retrovirus, it might be susceptible to antiviral drugs that are licensed for the treatment of AIDS. AZT (azidothymidine) was previously found to block XMRV replication. A screen of forty-five compounds reveals that XMRV …
Hosts: Vincent Racaniello and Stephen Goff Vincent speaks with Stephen Goff about the origin of the retrovirus XMRV and its association with prostate cancer and chronic fatigue syndrome. This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $75-$500 off a Drobo. Win a free Drobo S! Contest rules here. …
