cancer

Trial By Error: Why Did the NIH List an Award for Research on Cancer-Related Fatigue in Its List of Spending on ME/CFS?

1 Comment / Uncategorized / By David Tuller

By David Tuller, DrPH*April is crowdfunding month at UC Berkeley. If you like my work, consider making a tax-deductible donation to Berkeley’s School of Public Health to support the Trial By Error project: https://crowdfund.berkeley.edu/project/37217 Each year, the US National Institutes of Health publishes its “estimates of funding for various research, condition, and disease categories.” These estimates …

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An mRNA Vaccine to Treat Cancer

by Gertrud U. Rey There are several highly effective vaccines that block infection by human papillomaviruses (HPVs) and thereby prevent the cervical, anogenital, and head and neck cancers caused by these viruses. However, none of these vaccines are effective for the treatment of established HPV-induced tumors. The success of the COVID-19 messenger RNA (mRNA) vaccines …

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TWiV 531: Circ du RNA

This Week in Virology / By Vincent Racaniello

Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses. Click arrow to play Download TWiV 530 (65 MB .mp3, 107 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

RNA in circles

1 Comment / Basic virology, Information / By Vincent Racaniello

The diversity of cellular RNA structure and function has progressed from the early days of molecular biology, when we thought only about mRNA, tRNA and ribosomal RNAs. Then RNA splicing was discovered along with the many small nuclear RNAs that mediate that process. Next came small interfering RNAs and microRNAs and long noncoding RNAs, master …

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A new function for oncoproteins of DNA tumor viruses

2 Comments / Basic virology, Information / By Vincent Racaniello

Oncogenes of DNA tumor viruses encode proteins that cause cells to divide incessantly, eventually leading to formation of a tumor. These oncoproteins have now been found to antagonize the innate immune response of the cell (link to paper). Most cells encountered by viruses are not dividing, and hence do not efficiently support viral DNA synthesis. The …

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