The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Click arrow to play Download TWiV 543 (65 MB .mp3, 108 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: …
The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.  Click arrow to play Download TWiV 519 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Alois Alzheimer was the first to propose that an infection might play a role in the disease named after him. Herpes simplex virus type 1 (HSV-1) has been most frequently linked to Alzheimer€™s Disease (AD), and a clinical trial is in progress to determine if antivirals ameliorate its development. What is the evidence that HSV-1 …
The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer’s disease. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: …
Risk factors for the chronic neurodegenerative condition known as Alzheimer€™s disease (AD) include many cellular genes and pathogenic microbes. Nucleic acids of two ubiquitous human herpesviruses, HHV-6A and HHV-7, have been found at higher levels in AD brains compared with healthy controls, and appear to regulate genes implicated in risk of developing the disease.
