AIDS

Raltegravir inhibits murine leukemia virus: implications for chronic fatigue syndrome?

27 Comments / Basic virology, Information / By

The finding that a retrovirus, XMRV, is associated with chronic fatigue syndrome has lead to the suggestion that the disease might be treated with some of the antiviral drugs used to treat AIDS. The integrase inhibitor Raltegravir has been found to block the replication of murine leukemia virus, which is highly related to XMRV. But …

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TWiV 52: Scott Hammer, MD on AIDS vaccines

This Week in Virology / By

Hosts: Vincent Racaniello and Scott Hammer, MD On episode #52 of the podcast “This Week in Virology”, Vincent and Dr. Scott Hammer talk about different types of AIDS vaccines and how they are tested in clinical trials. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV052.mp3″] Click the arrow above to play, or right-click to download TWiV #52 (51 MB .mp3, 71 …

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Polyomavirus JC, multiple sclerosis, Tysabri, and an anti-malaria drug

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Biogen has announced that an anti-malaria compound may be useful for treating a brain infection, progressive multifocal leukoencephalopathy (PML), that is an adverse effect of the company’s multiple sclerosis/Crohn’s disease drug Tysabri. How does JC virus fit into this story? Tysabri is the trade name for Natalizumab, a monoclonal antibody against the cellular protein alpha-4 integrin. …

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