Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson continue virology 101 with a discussion of information flow from RNA to DNA, a process known as reverse transcription, which occurs in cells infected with retroviruses, hepatitis B virus, cauliflower mosaic virus, foamy viruses, and even in uninfected cells. This episode is sponsored by Data Robotics …
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich discuss ten compelling virology stories of 2009. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV064.mp3″] Click the arrow above to play, or right-click to download TWiV #64 (68 MB .mp3, 94 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by …
In the summer of 1989, two papers about viruses were published in high-profile journals. One described the engineering of a recombinant poliovirus bearing on its surface an antigen from HIV-1. The second paper claimed that transgenic mice could be made by adding DNA to sperm before using them to fertilize eggs. Both reports played a …
Viruses and journalism: Poliovirus, HIV, and sperm Read More »
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove On episode #62 of the podcast This Week in Virology, Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human …
Xenotropic murine leukemia virus related virus (XMRV) has been implicated in prostate cancer and chronic fatigue syndrome (CFS). Because XMRV is a retrovirus, it has been suggested that it might be susceptible to some of the many drugs available for treatment of AIDS. Of ten licensed compounds evaluated for activity against XMRV, just one, AZT …
The finding that a retrovirus, XMRV, is associated with chronic fatigue syndrome has lead to the suggestion that the disease might be treated with some of the antiviral drugs used to treat AIDS. The integrase inhibitor Raltegravir has been found to block the replication of murine leukemia virus, which is highly related to XMRV. But …
Raltegravir inhibits murine leukemia virus: implications for chronic fatigue syndrome? Read More »
