Describing a viral quasispecies
…the estimated mutation rate of an RNA virus. CirSeq was used to characterize poliovirus populations produced by seven serial passages in HeLa cells. The calculated mutation frequency, 2 X 10-4…
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Universal influenza vaccines
…from the 2006-2007 influenza season, then boosted with a recombinant adenovirus encoding the same HA protein. Sera from immunized mice neutralized strains of H1N1 influenza virus dating to 1934, as…
Thirty years of infectious enthusiasm
…on cloning complete genomes from pathogenic viruses in bacterial plasmid vectors had just been lifted. Consequently David suggested that I construct a full-length DNA copy of the poliovirus RNA genome,…
Unexpected endogenous viruses
…record from which it is possible to determine the age of viruses. The first non-retroviral endogenous virus described was bornavirus, a virus with a negative-stranded RNA genome. Bornaviral sequences were…
A human rhinovirus in chimpanzees
…during this outbreak of respiratory disease. Clinical signs observed are consistent with infections by rhinovirus C, but it is also possible that other viruses were involved. Rhinovirus C was previously…
Should we worry about avian influenza?
…scientists feel that it is only a matter of time before the viruses acquire this property. Or is it? Avian H5 influenza viruses have apparently been infecting humans for years….