Viral evasion of innate host defenses
…viruses encode proteins that interfere with this sensing pathway – influenza virus, HIV-1, vaccinia virus (VV), Ebolavirus, hepatitis C virus, hepatitis A virus (HAV), herpes simplex virus (HSV), and Kaposi’s…
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Riding the influenza pandemic wave
…more lethal virus. What is the evidence that pandemic waves of increasing virulence are a consequence of viral mutation? The only virus available from the 1918 pandemic was rescued from…
Holiday travel explains spread of a SARS-CoV-2 variant
…I would argue that studying the infectivity of a pseudotyped virus – in this case a lentivirus bearing the SARS-CoV-2 spike – in 293 cells (possibly human embryonic kidney) has…
Measurement of viruses by end-point dilution assay
The plaque assay is a terrific method for determining virus titers, but it doesn’t work for all viruses. Fortunately there are several alternative methods available, including the end-point dilution assay….
Gut microbes influence defense against influenza
…of immune defenses against influenza virus infection. When the gut microbiome of mice is altered by treatment with antibiotics, subsequent intranasal infection with influenza A virus leads to reduced antiviral…
What if influenza virus did not reassort?
…similar way to reduce or eliminate their ability to form reassortant viruses. Some have speculated that replacement of all the influenza viruses on the globe with reassortment-defective influenza viruses would…