Viral evasion of innate host defenses
…and MDA5 detect double-stranded or single-stranded RNA, leading to a series of reactions and the synthesis of cytokines such as IFN. As shown in the diagram below, each step of…
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Conversations from Penn State: Emerging Diseases
In the current episode of the Penn State University interview series called “Conversations from Penn State“, Peter Hudson, who is Willaman professor of biology and director of Penn State’s Huck…
The inflammatory response
…Within seconds, a series of signals is initiated that leads to cell death, an attempt to prevent the spread of infection. Inflammation is a very prominent response to TNF-α. There…
Influenza neuraminidase and H5N1 pathogenicity
…series of H5N1 reassortant viruses with NA stalks of different lengths. Six of the 8 viral RNAs were derived from the 1933 H1N1 isolate WSN. The pathogenicity of the reassortant…
XMRV infection of Rhesus macaques
…readily addressed by inoculating rhesus macaques via different routes. Studying viral pathogenesis (the series of events that occur during viral infection of a host) in animals is essential for understanding…
TWiV 156: Armed and targeted killer meta-analysis
…and two) Dickson – Wild Russia and Wild China TV series Vincent – Baculovirus molecular biology by George Rohrmann (free) Listener Pick of the Week Jim – Lee Cronin: Making…