Trial by Error, Continued: Is PACE a Case of Research Misconduct?
…research misconduct since I started my PACE investigation. In my long Virology Blog series in October 2015, I decided to document the trial’s extensive list of flaws, or as many…
…research misconduct since I started my PACE investigation. In my long Virology Blog series in October 2015, I decided to document the trial’s extensive list of flaws, or as many…
…they had done. In particular, the letter noted that the investigators extended a feasibility trial into a full trial while at the same time swapping primary and secondary outcome measures,…
…per the original protocol methods, or statistical analyses assessing the impact of the many mid-trial changes, or their actual trial data, they were able to hide their disastrous results for…
…with the MAGENTA trial report if that previous effort hadn’t been exposed. Instead of lying about the study’s peculiar feasibility-trial-into-full-trial design, they acknowledge it and concede that it is a…
…design a trial. He claims the SMILE trial’s results also undermine the PACE trial €“ which also used an unblinded trial with subjective outcomes €“ by showing that “the same…
…protocol). The investigators then publish their small randomized trial as a feasibility study for a new and bigger randomized trial, without disclosing in the paper that it did not start…