Trial By Error: A Reuters Update
…his open letters. PACE was a poorly designed and executed clinical trial. Racaniello added this: The PACE trial illustrates exactly how NOT to conduct a clinical trial. My Columbia colleague,…
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Trial By Error, Continued: Questions for Dr. White and his PACE Colleagues
…not, why not? A biostatistics professor from Columbia told me that for investigators to publish such information during a trial was “the height of clinical trial amateurism,” and that at…
Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet
…with problems of systemic bias in trial execution.” Studies with this design, he explained, have been abandoned in other fields of medicine. The difficulty of shielding such trials from systematic…
Trial By Error: Now a Scottish Long Covid Study Fails to Mention the Risk of Post-Exertional Malaise
…Trial By Error project: https://crowdfund.berkeley.edu/project/31347 And here’s another major trial designed by investigators who think that an exercise program might be the optimal strategy for treating the complex grab-bag of conditions…
Trial by Error, Continued: Is PACE a Case of Research Misconduct?
…research misconduct since I started my PACE investigation. In my long Virology Blog series in October 2015, I decided to document the trial’s extensive list of flaws, or as many…
Trial By Error: My Exchange With Archives of Disease in Childhood
…they had done. In particular, the letter noted that the investigators extended a feasibility trial into a full trial while at the same time swapping primary and secondary outcome measures,…