…was already the prevailing treatment approach. In 2003, government agencies approved funding for the PACE trial, which the investigators themselves hailed as the “definitive” trial of the interventions. In setting…
…2003, government agencies approved funding for the PACE trial, which the investigators themselves hailed as the “definitive” trial of the interventions. In setting out the rationale for the intervention, the…
By David Tuller, DrPH When I first began examining the PACE trial in detail, I turned to clinical trial experts to vet my concerns. One of them was biostatistician Bruce…
…have included links below to: the protocol for the feasibility trial, the protocol for the full trial, the trial registration and the feasibility trial paper. Thanks again for your attention…
…with the study is that patients cannot be enrolled in a trial before the trial itself is registered. Furthermore, the primary and secondary outcome measures were changed during the trial….
…trial, or whether this was intended as a fully powered trial. Throughout, I think this needs to be clarified for the reader and interpretations/conclusions drawn in light of what the…
