…assessing quality of clinical trial evidence. The document focuses on reducing the stringency of RoB assessment principally in unblinded trials. My immediate reaction to this was that it is a…
…study was rephrased as a feasibility trial when the intervention failed to provide the expected effect sizes. The trial was only powered to detect large effects and both the protocol…
…in response to that: 1) A trial can be “the largest” and still be crap. 2) Professor Crawley and her team did not read this important trial document carefully enough…
…more than declare the trial to be “profoundly flawed.” In his comments, he touched on one of the main negative consequences of the PACE debacle–the fact that the trial and/or…
…Conduct a Randomized Clinical Trial.” The trial was harshly criticized in a letter to The Lancet signed by more than 100 experts and a host of international organizations (I wrote…
…CODES was the largest trial of dissociative seizures, this new FND study–“Specialist physiotherapy for functional motor disorder in England and Scotland (Physio4FMD): a pragmatic, multicentre, phase 3 randomised controlled trial”–represented…
